Transparent organic bistable memory device with pure organic active material and Al/indium tin oxide electrode

Transparent organic bistable memory devices OBDs were developed by employing indium tin oxide ITO as an anode and a cathode for OBD. A cathode structure of aluminum Al /ITO was used and bistability could be realized with pure polyphenylenevilylene based polymer active material without any metal nanoparticle. Transmittance of over 50% could be obtained in Al/ITO based OBD at an Al thickness of 10 nm, and an average on/off ratio around 100 was observed

Organic light emitting bistable memory device with high on/off ratio and low driving voltage

Organic light emitting bistable memory devices (OLEBDs) with a dual function of organic light emitting diodes and organic memory devices were developed by using 0.5 nm thick MoO3 as an interlayer between hole injection layer and hole transport layer. The hole transport unit with MoO3 interlayer played a role of a memory unit as well as a hole transport unit. High on/off ratio over 1000 was obtained at a reading voltage of 1 V and driving voltage was lowered by MoO3. In addition, two different luminances were obtained at the same driving voltage by changing writing voltage of OLEBDs

Stable efficiency roll-off in phosphorescent organic light-emitting diodes

Origin of efficiency roll-off in phosphorescent organic light-emitting diodes was investigated with triplet mixed host devices and stable devices with little efficiency roll-off was developed. Efficiency roll-off was significant in the device with narrow recombination zone RZ and charge leakage out of emitting layer at high luminance was critical to efficiency roll-off. Efficiency roll-off could be reduced in triplet mixed host device with broad RZ and little charge leakage at high driving voltage. Triplet mixed host devices with an exciton blocking layer showed a quantum efficiency over 90% of maximum quantum efficiency at a luminance of 20 000 cd/m2.Grant No. RTI04-01-02 from the Regional Technology Innovation Program of the Ministry of Commerce, Industry and Energy (MOCIE

Convergence Circuit Mapping: Genetic Approaches From Structure to Function

Understanding the complex neural circuits that underpin brain function and behavior has been a long-standing goal of neuroscience. Yet this is no small feat considering the interconnectedness of neurons and other cell types, both within and across brain regions. In this review, we describe recent advances in mouse molecular genetic engineering that can be used to integrate information on brain activity and structure at regional, cellular, and subcellular levels. The convergence of structural inputs can be mapped throughout the brain in a cell type-specific manner by antero- and retrograde viral systems expressing various fluorescent proteins and genetic switches. Furthermore, neural activity can be manipulated using opto- and chemo-genetic tools to interrogate the functional significance of this input convergence. Monitoring neuronal activity is obtained with precise spatiotemporal resolution using genetically encoded sensors for calcium changes and specific neurotransmitters. Combining these genetically engineered mapping tools is a compelling approach for unraveling the structural and functional brain architecture of complex behaviors and malfunctioned states of neurological disorders

DNA microarray-based experimental strategy for trustworthy expression profiling of the hippocampal genes by astaxanthin supplementation in adult mouse

Naturally occurring astaxantin (ASX) is one of the noticeable carotenoid and dietary supplement, which has strong antioxidant and anti-inflammatory properties, and neuroprotective effects in the brain through crossing the blood–brain barrier. Specially, we are interested in the role of ASX as a brain food. Although ASX has been suggested to have potential benefit to the brain function, the underlying molecular mechanisms and events mediating such effect remain unknown. Here we examined molecular factors in the hippocampus of adult mouse fed ASX diets (0.1% and 0.5% doses) using DNA microarray (Agilent 4 × 44 K whole mouse genome chip) analysis. In this study, we described in detail our experimental workflow and protocol, and validated quality controls with the housekeeping gene expression (Gapdh and Beta-actin) on the dye-swap based approach to advocate our microarray data, which have been uploaded to Gene Expression Omnibus (accession number GSE62197) as a gene resource for the scientific community. This data will also form an important basis for further detailed experiments and bioinformatics analysis with an aim to unravel the potential molecular pathways or mechanisms underlying the positive effects of ASX supplementation on the brain, in particular the hippocampus

Triplet host engineering for triplet exciton management in phosphorescent organic light-emitting diodes

The device performances of green phosphorescent organic light-emitting diodes with a triplet mixed host emitting layer were correlated with the energy levels and composition of the host materials. Two hole-transport-type host materials, (4,4-N,N -dicarbazole)biphenyl (CBP) and 4,4 ,4 - tris(N-carbazolyl)triphenylamine (TCTA), were combined with two electron-transport-type host materials, 1,3,5-tris(N-phenylbenzimidazole-2-yl)benzene (TPBI) and PH1. The maximum quantum efficiency was obtained in the 5:5 mixed host in the case of TCTA:TPBI and TCTA:PH1, while CBP:PH1 showed the best performances in the 9:1 mixed host. The quantum efficiency of the green mixed host devices was improved by more than 50% compared with that of the corresponding single host devices.Grant No. RTI04-01-02 from the Regional Technology Innovation Program of the Ministry of Commerce, Industry and Energy (MOCIE

Breathing Exercises for Improving Cognitive Function in Patients with Stroke

Patients with stroke may experience a certain degree of cognitive decline during the period of recovery, and a considerable number of such patients have been reported to show permanent cognitive damage. Therefore, the period of recovery and rehabilitation following stroke is critical for rapid cognitive functional improvements. As dysfunctional breathing has been reported as one of the factors affecting the quality of life post stroke, a number of studies have focused on the need for improving the breathing function in these patients. Numerous breathing exercises have been reported to enhance the respiratory, pulmonary, cognitive, and psychological functions. However, scientific evidence on the underlying mechanisms by which these exercises improve cognitive function is scattered at best. Therefore, it has been difficult to establish a protocol of breathing exercises for patients with stroke. In this review, we summarize the psychological, vascular, sleep-related, and biochemical factors influencing cognition in patients and highlight the need for breathing exercises based on existing studies. Breathing exercises are expected to contribute to improvements in cognitive function in stroke based on a diverse array of supporting evidence. With relevant follow-up studies, a protocol of breathing exercises can be developed for improving the cognitive function in patients with stroke

Potential Biomarkers of Peripheral and Central Fatigue in High-Intensity Trained Athletes at High-Temperature: A Pilot Study with Momordica charantia (Bitter Melon)

Among potent dietary supplements, Momordica charantia, commonly called bitter melon, has various biological effects, such as antioxidant and anti-inflammatory effects, and improves energy metabolism and fatigue recovery. However, it is unknown whether Momordica charantia extract (MCE) induces antifatigue effects during exercise training in high-temperature environments. This study aimed at investigating the efficacy of MCE by examining 10 male tennis players consuming 100 mL MCE/dose (6 times a day over 4 weeks) during the summer training season. Peripheral (ammonia and uric acid) and central (serotonin, dopamine, and prolactin) fatigue parameters were measured before and after MCE consumption; before, during, and after exercise; and the next morning. After consuming MCE supplements, ammonia levels were higher during and after exercise and recovered the next morning, whereas uric acid levels did not change at any time point. Serotonin levels were lower during exercise. Dopamine levels were higher, especially during exercise. Prolactin levels were lower at all time points, especially during and after exercise. Although high-intensity training in a hot environment causes accumulation of fatigue-related metabolites, our results indicate that 4 weeks of MCE intake positively influenced fatigue parameters, suggesting that MCE can efficiently combat fatigue

DNA microarray-based experimental strategy for trustworthy expression profiling of the hippocampal genes by astaxanthin supplementation in adult mouse

Naturally occurring astaxantin (ASX) is one of the noticeable carotenoid and dietary supplement, which has strong antioxidant and anti-inflammatory properties, and neuroprotective effects in the brain through crossing the blood–brain barrier. Specially, we are interested in the role of ASX as a brain food. Although ASX has been suggested to have potential benefit to the brain function, the underlying molecular mechanisms and events mediating such effect remain unknown. Here we examined molecular factors in the hippocampus of adult mouse fed ASX diets (0.1% and 0.5% doses) using DNA microarray (Agilent 4 × 44 K whole mouse genome chip) analysis. In this study, we described in detail our experimental workflow and protocol, and validated quality controls with the housekeeping gene expression (Gapdh and Beta-actin) on the dye-swap based approach to advocate our microarray data, which have been uploaded to Gene Expression Omnibus (accession number GSE62197) as a gene resource for the scientific community. This data will also form an important basis for further detailed experiments and bioinformatics analysis with an aim to unravel the potential molecular pathways or mechanisms underlying the positive effects of ASX supplementation on the brain, in particular the hippocampus. Keywords: Astaxanthin supplementation, Dose-dependent, Hippocampal genes, Housekeeping gene, RT-PC

Correlation of memory characteristics of polymer bistable memory devices with metal deposition process

Origin of bistability in organic bistable memory devices (OBDs) was investigated by using two metal deposition processes of electron beam deposition and thermal deposition. Thermal deposition of Al was more effective than electron beam deposition to get high on/off ratio and stable operation of OBDs and metal nanoparticle formation during metal deposition was found to be critical to bistability of polymer OBDs